Figure 4: Identification of a FGF-2 high-affinity binder in the heparan ... providing a ready methodology to probe cell function and discover novel drug targets, SNA-MS should provide a foundation ...

a characteristic which may not hold for FGF-2. The structures presented by DiGabriele et al. 16 provide a significant new piece to the puzzle of how heparin activates the FGF signaling pathway.