Context: Fatal familial insomnia (FFI) is a genetically transmitted neurodegenerative prion disease that incurs great suffering and has neither a treatment nor a cure. The clinical literature is ...

Affected populations: The disease affects an estimated 1 to 2 people per million every year, according to the National Organization of Rare Disorders. FFI is passed from parent to child ...

She belongs to a family carrying the gene for fatal familial insomnia. The main symptom of FFI, as the disease is often called, is the inability to sleep. First the ability to nap disappears ...

In FFI, circadian rhythms break down and the distinction between day and night is blurred. Temperature decline associated with chronic sleep deprivation does not occur in patients with FFI.

More efficient water use in countries that share rivers and water tables, reduction in pollution, and stronger infectious disease control are just a few examples of these externalities. The FFI is a ...