Upon uptake, proteins and soluble components from the extracellular space pass through endosomes before fusing and/or maturing to form lysosomes. During the endosome–lysosome transition ...

In addition, vesicles that bud off from the plasma membrane via endocytosis are also sent to lysosomes, where their contents — fluid and molecules from the extracellular environment — are ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

Cargo trafficking via extracellular vesicles (EVs) is a vital biological process for cellular communication ... We hypothesized that the reason for this reduction of EV cargoes in nwk mutants is that ...

α2M and clusterin are molecular chaperones involved in extracellular proteostasis, but α2M has a greater affinity for aggregation-prone proteins. Disclaimer: AAAS and EurekAlert! are not ...

Lysosomes are organelles found within nearly ... Focal adhesions (FAs) are structures that connect cells to the extracellular matrix (ECM) (the cell's external surroundings), composed of collagen ...

Our research uncovers the mechanisms by which T cells adjust to extracellular nutrient conditions and connect them to a key ...