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生物通
9 天
EphB4-ephrin-B2:前列腺癌治疗的新希望
研究结论和讨论部分指出,EphB4-ephrin-B2 通路在前列腺癌的早期就被诱导,对肿瘤的起始和进展都有促进作用。该通路与 PI3K p110β 之间存在正向调控关系,并且在去势抵抗性前列腺癌中,EphB4-ephrin-B2 通路的抑制会导致 c-Myc 和雄激素受体(AR)的下调。这一研究揭示了 EphB4-ephrin-B2 ...
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