Enhancers were formerly believed to be modular. Each enhancer occupies a separate region of DNA, as the term suggests. “We have shown, however, that this is not absolutely true," explained ...

In this study, the researchers decided to look into the role of DNA sequences known as enhancers and promoters, and how their spatial distance impacts transcriptional bursting. The promoter is ...

研究人员利用尖端技术，研究了转录因子的组合如何驱动不同的细胞身份，比如胚胎细胞和胎盘细胞。他们的研究结果表明，转录因子会根据染色质景观的不同进行动态合作或竞争，以精确锁定对确定细胞类型至关重要的基因。

New research from the Furlong group at EMBL Heidelberg has identified a shift in how genes are regulated by DNA control regions called enhancers during the differentiation process, as cells go ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are therefore separated from each other, even if they control the ...

Enhancers, on the other hand, are often many hundreds of thousands of bases away from the gene, but as DNA strands move and fold, enhancers can still end up close to genes in 3D space, amplifying ...

In part 2 of this webinar, Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilizing the 6-base genome to ...

In this study, the researchers decided to look into the role of DNA sequences known as enhancers and promoters, and how their spatial distance impacts transcriptional bursting. The promoter is ...