Also, therapeutics leveraging endocytosis-mediated lysosomal degradation, such as lysosome-targeting chimeras (LYTACs), may have penetration issues in the blood–brain barrier (BBB) or tumor ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms that control the endocytosis itself are largely ...

(3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation. (4) Depolarised mitochondria undergo morphological remodelling to squeeze their ...