inhibiting the G1/S transition and causing G2/M arrest during cell cycle progression. The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB ...

One downstream consequence of RB activity is the inhibition of E2F activity, which is important for the transcription of several genes that are required for progression through the G1 and S phases ...

and resulting in the E2F-mediated stimulation of genes involved in the G1 → S transition. The E7 proteins of high-and low-risk HPV strains share a specific amino acid difference in their pRb ...