During the S (DNA-replication) phase of the cell cycle ... transcription of genes governed by the cyclin D–Cdk4/6→Rb→E2F pathway (Fig. 2). These findings are important because they provide ...

The pRB/E2F signaling pathway is controlled by DNA methyltransferase-1 (Dnmt-1). The elevated expression of Dnmt-1 has been reported in carcinomas of the colon, lung and prostate. A defect of pRB ...