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Combining epigenetic cancer medications may have benefit for colorectal cancers and other tumor types
"DNMT inhibitors are approved to treat blood cancer while EZH2 inhibitors are approved to treat blood cancer and a rare type of sarcoma. To date, they've had limited individual success in solid ...
Nature13y
Molecular basis for the actions of Hsp90 inhibitors and cancer therapy
The pRB/E2F signaling pathway is controlled by DNA methyltransferase-1 (Dnmt-1). The elevated expression of Dnmt-1 has been reported in carcinomas of the colon, lung and prostate. A defect of pRB ...