Medically reviewed by Alex Yampolsky, PharmD Hydroxyzine, whose brand names include Atarax and Vistaril, and Benadryl, the ...

Benadryl is often taken in two forms: Orally: Benadryl can be taken by mouth in pill or liquid form. Topically: It can be applied to the skin in the form of a cream, gel, or spray. There are ...

The Food and Drug Administration (FDA) has not approved Benadryl, which contains the active ingredient diphenhydramine, to treat anxiety. The medication is also not intended for long-term use.