A primary degradation signal (degron) of a short-lived protein is a feature of that protein (for example, a segment of its amino acid sequence) that functions as a target of a proteolytic pathway.

However, we have a group of ‘essential genes’ that we cannot remove because it results in cell death.” To overcome this, Adli and colleagues utilize reversible auxin-inducible degron (AID) tools that ...

The structure reveals that the ORF10 N-terminal heptapeptide (NTH) mimics the Gly/N-degron to bind CUL2 ZYG11B. Mutagenesis studies identified key residues within ORF10 that are key players in its ...