For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these is a segment between the first two strands of the Ig-fold, referred to as the A ...

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions ...

This imaging showed that smaller proteins bind to the end of the filament — to stabilize the RAD51’s DNA binding, before detaching and repeating the process further along. This, in turn ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific DNA sequences along with the bound proteins. By using enzymes ...

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein, and its interaction with DNA polymerase. However, they first needed to establish how the ...

KBSI researchers block TDP-43 protein aggregation using graphene quantum dots KBSI scientists enhance nerve cell protection ...

Research has identified a critical DNA repair protein that drives the expansion of certain genetic sequences at the heart of Huntington’s disease. This breakthrough could lead to treatments that ...

In a groundbreaking study, scientists from Karolinska Institutet discovered that water molecules are crucial in helping transcription factors, proteins that regulate gene activity, read the human ...