DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

On one hand, it represses PARP1 catalytic activity and associated DNA damage repair. On the other hand ... patients with cancer who have developed resistance to PARP1 inhibitors, according ...

TMZ works by introducing DNA damage, specifically a modification ... it became clear that DNA repair pathways underlying drug resistance are redundant, i.e., when one pathway is inactivated ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

The team hypothesized that hydrogen peroxide levels below the detection of HyPer7 could still induce DNA damage. While nuclear DAAO activation kick-started DNA damage repair proteins and caused DNA ...

A new study has said that if cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know about the issue. A new study has said that if cells ...

In a video interview, William K. Oh, MD, director of precision medicine at Yale Cancer Center and Smilow Cancer Hospital discusses the latest breakthroughs in advanced prostate cancer treatment.