In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

Researchers led by Prof. TONG Minghan from the Center for Excellence in Molecular Cell Science of the Chinese Academy of Sciences, collaborating with Prof. HUANG Ying from Xinhua Hospital, Shanghai ...

DNA damage and repair refers to the creation ... SRBD1 as a key mediator of these essential processes that localizes topoisomerase IIα to mitotic chromosomes. AAV vectors are a promising gene ...

DSB formation by Spo11 is biochemically similar to action of type II topoisomerases, enzymes that normally work to create a transient gate in a DNA duplex by breaking both strands via a covalent ...

Their research proposes that PICH protects human DNA through two key mechanisms. First, it assists another protein, topoisomerase IIα (TOP2A), in untangling the DNA threads. Second, it works with ...