This study highlights the importance of proteins that are involved in the regulation of the actin cytoskeleton, revealing fundamental roles for HEM1 in both innate and adaptive immune cells.

Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...

However, most animal cells have complex morphologies because the membrane adheres strongly to the cytoskeleton. In animal cells, movement of membrane into an endocytic vesicle or lamellipodium ...

3D microscope image showing separation of actin isoforms in a cluster of cells. The uppermost layer (stained red) consists of gamma actin, whilst the base and edges display beta actin (green ...

We recently discovered that these structures are essential for the establishment of reticular adhesions. In our lab, we aim to elucidate the interplay of clathrin structures with the actin ...