For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...

My research focuses on the segregation of chromosomes during cell division. Chromosomes are the bodies that contain our DNA and it’s critical that each cell has the correct DNA in the correct quantity ...

One of the most powerful weapons that cancer cells have at their disposal is CIN, which involves randomly shuffling their chromosomes each time they divide. (See illustration on opposite page.) Errors ...

This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. The study is ...

This figure depicts chromosome segregation errors in meiosis. (A) The three main classes of segregation errors. (B) Incorrect alignment of chromosome kinetochores (C) Mitotic spindle errors.

Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

The so-called Robertsonian (Rb) fusions that led to these rapid karyotype changes are relatively common chromosomal rearrangements. But their accumulation in the populations of Madeira Island and in ...

We now know that this complex plays important roles in several chromosomal activities, such as replication, repair, and segregation. Our understanding of this complex is just beginning, but it ...

Crossovers establish a physical connection between homologous chromosomes thereby ensuring their faithful segregation. Crossovers are non-randomly distributed along the genome, suggesting a mechanism ...