For example, the use of small-molecule modifiers of DNA, and later dideoxy nucleoside triphosphates ... Determining structures of large molecular assemblies by methods including crystallography ...

Nucleic acids are macromolecules, which means they are molecules composed of many smaller molecular units. Thes units are called nucleotides, and they are chemically linked to one another in a chain.

Our research focuses on all aspects of nucleic acid structure, chemistry and function employing state of the art technologies and approaches. Our goal is to generate a better understanding of how ...