来自MSN9 个月
The 'switch' that keeps the immune system from attacking the body
One of its central components is the enzyme cyclic GMP-AMP synthase (cGAS), which acts as a sentinel, detecting foreign DNA and initiating an immune response. However, the immune system requires ...
BioWorld15 天
Potent, selective ENNP1 inhibitor with robust antitumor effects
ENPP1 contributes to establishing an immunosuppressive tumor microenvironment by blocking the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling, which is critical in ...