This suggests that Cdk5/DARPP-32 provides a feedback signal that compensates for an upregulated PKA pathway. The fact that ΔFosB accumulates following repeated cocaine exposure and persists ...

Hydrogen peroxide, however, affects several signaling pathways ... Figure 1: Cyclin-dependent kinase 5 (Cdk5) downregulates peroxiredoxin-2 (Prx2) activity, leading to an accumulation of reactive ...