Both Cas9 and Cas12a cleave DNA, but they differ in how they cut the molecule.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... demonstrating its effective application in various microorganisms. Cas12a represents the next generation of gene editing.

In contrast to Cas9, Cas12a can delete multiple genes at the same time with extremely high efficiency.” The researchers also used Cas12a in combination with other genome engineering tools ...

While Cas9 has been the predominant enzyme in CRISPR applications over the past decade, Cas12a offers advantages. “In contrast to Cas9, Cas12a can delete multiple genes at the same time with ...

In contrast to Cas9, Cas12a can delete multiple genes at the same time with extremely high efficiency." The researchers also used Cas12a in combination with other genome engineering tools ...