Switching from immediate-release carvedilol: see literature. ≥65yrs: switching from highest dose of immediate-release carvedilol (25mg twice daily) to Coreg CR: initially Coreg CR 40mg ...

The major factors to be kept in mind when switching to carvedilol are maintaining adequate β blockade to avoid the potential for precipitating ischemia or arrhythmias, choosing an initial dose ...

carvedilol or vice versa with regards to tolerability to target doses, but the reasons for not reaching the primary endpoint and the clinical reaction to the beta-blockers differed.