Carvedilol has the capacity to block both the β-1 and β-2 adrenergic receptors, as well as the α-1 receptors. There is evidence to indicate that full adrenergic blockade by carvedilol improves ...

[9] Food decreases the absorption of carvedilol, with prolongation of time to peak plasma level but without alteration of the degree of drug absorption. [9] For clinical use, it is recommended ...

The use of ISMN plus NSBBs leads to response in an additional one-third of HVPGs nonresponders, with a corresponding decrease in their bleeding risk. Carvedilol was introduced several years ago.