Scientists in Jianmin Cui's lab at Washington University in St. Louis study ion channels important in heart contraction and neural activity. Many experiments involve mutating the DNA that codes ...

These translational studies are aimed at developing new therapeutic targets for heart disease. Proper contraction and relaxation of the heart depends on the coordinated flux of calcium ions in and out ...

Areas of expertise My research is focused on cardiac excitation-contraction coupling and its regulation. Using a variety of techniques (for example voltage clamp, fluorescent ion indicators,whole cell ...

The uptake and release of calcium ions by the sarcotubular system are believed to be an integral part of excitation–contraction coupling and relaxation of muscle, and so it is important to ...