在一项新的研究中，来自南卡罗来纳医科大学霍林斯癌症中心的研究人员揭示了如何设计嵌合抗原受体（chimeric antigen receptor, CAR）Treg细胞的新规则。这一突破可能为对抗1型糖尿病等自身免疫性疾病提供更有效的工具。

In this study, researchers aimed to understand how CAR T cells with different signaling domains work at the molecular and cellular levels to lay the foundation for designing CAR molecules that ...

A new advance may make it possible to use off-the-shelf CAR T cells provided by healthy donors. The new approach studied in mice equipped CAR T cells with the viral protein Nef.

In this study, researchers aimed to understand how CAR T cells with different signaling domains work at the molecular and cellular levels to lay the foundation for designing CAR molecules that ...

This enabled fast CAR T cell recovery and a mastery of "serial killing" of cancer cells. In contrast, researchers found that 4-1BB.ζ-CAR molecules linger in the lipid rafts and immune synapse.

To create one of the most advanced immunotherapies in cancer, CAR-T cell therapies, scientists engineer immune T cells to carry a synthetic protein on their surfaces. This protein, called the ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer. Investigators from Baylor College of ...

CAR-T cell immunotherapy involves harvesting immune ... suggesting that further study into their functions and signaling pathways might reveal insights into how T cells differentiate, or change ...

This webinar presents an optimized assay workflow using the Agilent Seahorse XF Pro Analyzer to profile T cell energy metabolism, enhancing the design and manufacturing of CAR-T cell therapies.

CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a ...