The authors show that the voltage gated calcium channels are present on the lysosomes that dispose of proteins. In this study, “we argue that when the acidified lysosome is depolarized by a sodium ...

Calcium channels are ion channels that are triggered to open by either a change in the voltage across the membrane, which occurs in nerve cells propagating a signal, or by small molecule ligands ...

Other commonly-prescribed anti-seizure medications act on sodium and calcium channels in neurons, routes that are effective for some but not all patients. About 40% of the estimated 1.5 million ...

More importantly, when they dosed the cells with a sodium channel blocker called tetrodotoxin, they still found a signal.