The company's newest program is evaluating a series of internally developed dual amylin and calcitonin receptor agonists (or DACRAs) for the treatment of obesity and other metabolic disorders.

"We believe this transaction highlights a growing interest in amylin agonists (and particularly dual amylin-calcitonin receptor agonists, as DACRAs) as a next wave of obesity assets (emerges ...

GUB014295 is an amylin receptor agonist that also targets calcitonin receptors. Amylin analogues have been investigated for their role in appetite suppression and delayed gastric emptying ...

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Interventions: Oral alendronate 5mg, oral alfacalcidol 1 µg or intranasal calcitonin 200IU daily. Methods: We used the effects on bone mineral density (BMD) in head-to-head trials together with ...

Across 3 clinical trials, atogepant vs placebo was associated with reduced weekly and monthly migraine days by week 4. Atogepant, an oral calcitonin gene-related peptide receptor antagonist, ...

AbbVie said it will lead development and commercialization activities of GUB014295, an agonist that specifically activates amylin and calcitonin receptors that is currently in a Phase 1 study.