为探究 CYP2D6 基因多态性与中国乳腺癌患者血浆内依西美坦浓度关系，研究发现二者关联，且不影响他莫昔芬副作用。 在乳腺癌的治疗领域，内分泌治疗一直占据着举足轻重的地位，尤其是对于激素受体阳性（HR+）HER2 受体阴性（HER2-）的乳腺癌患者而言 ...

为探究 CYP2D6 活性与焦虑抑郁关系，研究人员对 96 名马来西亚人基因分型，发现其活性影响患病易感性。 在精神健康领域，基因与心理疾病的关联一直是研究的热点。细胞色素 P450 2D6（CYP2D6）作为一种参与多种药物和内源性物质代谢的酶，其与焦虑、抑郁等人格 ...

Genetic testing is transforming depression treatment by tailoring antidepressants to your DNA for better results and fewer ...

具体产品为人类CYP2D6基因多态性检测试剂盒（荧光PCR法），注册证编号为国械注准20243402615，有效期至2029年12月16日，用于体外定性检测人静脉全血 ...

Based on the feedback from the FDA, the Company’s regulatory data package would be sufficient for the submission of an sNDA for AXS-05 for the treatment of Alzheimer’s disease agitation. Axsome ...

The gene encodes an enzyme in the liver called CYP2D6. Subsequently, they tested different drug compounds on engineered cell models to determine how the effect of the compound was influenced by ...

Cardiovascular disease. Angle-closure glaucoma. Seizures. Psychosis. Poor metabolizers (those with reduced CYP2D6 activity). Avoid abrupt cessation. Write ℞ for smallest practical amount.

Concomitant strong CYP3A4 or CYP2D6 inhibitors, or CYP2D6 poor metabolizer: reduce aripiprazole dose by ½. Concomitant strong CYP3A4 inducers: double aripiprazole dose (max 30mg/day) over 1–2 ...