Thus, formed colistin is active against MDR bacteria and CMS is an inactive prodrug. Colistin displaces divalent cations from the phosphate groups of membrane lipids, which leads to disruption of ...

However, diagnostic-clinical microbiology is faced with a dilemma, because clinical thresholds to interpret resistance tests for these substances are available to a limited degree only. The CLSI ...

The review provide updated information to enable clinicians to choose this drug for proper use as a treatment option against pathogenic bacteria.