Follow-up tests include measuring the amount of salt in sweat and checking for mutations in the CFTR gene (the most expensive diagnostic). Currently about half a dozen states mandate CF screening ...
The Dualase genome editors are versatile, allowing repair of all mutation types, such as insertions ... transmembrane conductance regulator (Cftr) mutations. Preclinical studies of the RNA ...
Wild-type, stabilized and CF-causing CFTR variants are available ... “The allosteric effects of the F508del mutation in human CFTR elucidated by cryo-EM enabled by protein engineering,” presented by ...
in addition to maintenance of wild-type Sprague Dawley strain for additional use Generation and procurement of novel relevant CF animal models to understand newly developed CFTR modulators, and to ...
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause congenital bilateral absence of the vas deferens (CBAVD) in approximately 1% of the infertile males.