为解决慢性髓性白血病(CML)对 BCR-ABLi 耐药难题,俄罗斯科学院基因生物学研究所研究人员开展 CDK8/19 抑制对 CML 细胞影响的研究。发现 CDK8/19i 可增敏 BCR-ABLi,加速癌细胞死亡。极具科研价值,推荐一读! 俄罗斯科学院基因生物学研究所(Institute of Gene Biology ...
Our lab and others have shown that a four-subunit CDK8 module can reversibly associate with the 26-subunit Mediator complex. The CDK8 module is 600 kDa in size and consists of MED12, MED13, CDK8, and ...