We first studied the effects of high- fat diet (HFD) on Cd28KO, then on wild-type (WT) mice treated with an inhibitor of CD28/B7 interactions, CTLA4-Ig. We report that Cd28KO displayed larger ...

ETCTN 10483: Phase Ib trial of erdafitinib (E) combined with enfortumab vedotin (EV) following platinum and PD-1/L1 inhibitors for metastatic urothelial carcinoma (mUC) with FGFR3/2 genetic ...

T-cell-specific surface glycoprotein CD28, also known as TP44, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. It is a key co-stimulatory ...