Blocking G i protein–coupled receptor signaling by pertussis toxin as well as deficiencies in Gα i2, chemokine receptor 2 (CCR2), CCR5, chemokine ligand 2 (CCL2, also known as monocyte ...

5 After applying the CCL-2 ligand to the opposite end of the device, monocytes with functional CCR2 rushed up the density gradient toward their ligand. The patients’ cells, however, were unresponsive ...