Under conditions of low unfolded protein stress, the lumenal domains of PERK and IRE1 are in complex with the endoplasmic reticulum chaperone BiP, whose binding correlates with the inactive state ...

eukaryotic cells increase transcription of genes encoding ER-resident chaperones such as BiP/GRP78 and GRP94; this induction system is termed the unfolded protein response (UPR) 1. The mediators ...