为解决肝细胞癌（HCC）早期诊断困难和治疗耐药问题，郑州大学第一附属医院的研究人员开展 BRD4 相关基因研究。他们构建四基因预后模型，发现联合抑制剂可增效。这为 HCC 诊疗提供新思路，强烈推荐科研读者阅读。 郑州大学第一附属医院（Department of ...

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...

By targeting the ACLY-BRD4 pathway, the researchers were able ... microenvironment via the remodeling of pro-inflammatory enhancers, Cell Reports (2024). DOI: 10.1016/j.celrep.