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Mayo research sorts if rare BRCA2 mutations increase breast cancer risk
A Mayo Clinic-led team of researchers is solving one of the most frustrating aspects of genetic cancer screening — results that give zero guidance to patients on whether they are at elevated risk.
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Improving cancer risk assessment and patient care: Researchers resolve uncertainty in BRCA2 testing
The study, published in Nature, utilized CRISPR-Cas9 gene-editing technology to analyze the functional impact of almost 7,000 BRCA2 variants, definitively identifying those that increase cancer ...
People2y
'Biggest Loser's Heba Salama Opens Up About Life After the Show — and Testing Positive for BRCA2
She thought nothing of the routine genetic testing ordered by her doctor until she got an email in March 2020 revealing she was BRCA2 positive. According to the National Cancer Institute ...
Science Daily14d
Scientists upends scientific understanding of how anticancer drugs kill cancer
BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...
Scientists Capture First-Ever Images of Cancer’s Covert DNA Repair Strategy
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
MedPage Today4d
Second Primary Cancer Risks After Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers
Opens in a new tab or window We followed 25,811 females and 480 males diagnosed with BC and tested for germline BRCA1/BRCA2 PVs in NHS Clinical Genetics centers in England between 1995 and 2019 ...
CURE9d
Xtandi and Talzenna Therapy Shows Responses in Advanced Prostate Cancer
Dr. Chandler Park sat down for an interview with CURE® to discuss the biggest takeaway from the 2025 ASCO GU Symposium in ...
Frontiers1d
BRCA mutations and Homologous Recombination Deficiency (HRD) testing in ovarian cancer
Ovarian cancer (OC) is the fifth most common cause of cancer-related mortality worldwide and represents the leading cause of death for gynecological malignancies. Nevertheless, over the last years, ...
CURE15d
BRCA1/2 Mutations May Associate With Better Chemo Response in TNBC
Among patients with early-stage triple-negative breast cancer, a beneficial pathologic complete response rate was higher in ...
Medical Xpress25d
Research upends scientific understanding of how anticancer drugs work
Whalen, Ph.D., poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells. Their work, published in Nature Cancer, illustrates how a small DNA nick—a ...
Medical Xpress25d
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
For example, men with inherited or acquired mutations in BRCA2 or ATM genes are at heightened risk of aggressive disease and have worse outcomes than those who don't have these mutations ...
News Medical26d
Study challenges role of BRCA1 mutation in prostate cancer initiation
For example, men with inherited or acquired mutations in BRCA2 or ATM genes are at heightened risk of aggressive disease and have worse outcomes than those who don't have these mutations ...