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抗中性粒细胞细胞质抗体相关血管炎中的抗髓过氧化物酶IgM B细胞
选择部分抗 MPO - IgM 和抗 MPO - IgG BCR 序列制备单克隆抗体(mAbs),并通过多种方法检测其 MPO 反应性和特异性。 补体激活实验:通过 ELISA 检测抗 MPO - IgM mAbs 与 MPO 结合后 C1q 的沉积情况,评估其激活补体的能力。对 MPO + AAV 患者和对照的血浆进行大小排阻色谱 ...
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