本研究通过单细胞RNA测序分析1型糖尿病（T1D）患者外周血中胰岛抗原反应性B细胞的转录组和BCR特征，揭示其在疾病进展中的独特表型和克隆扩增现象，为T1D的早期诊断和治疗提供新思路。 本研究聚焦于1型糖尿病（T1D）患者外周血中胰岛抗原反应性B细胞的转录 ...

Genes that encode B cell receptors (BCRs ... of ‘fingerprint’ of current and prior exposures. Therefore, TCR and BCR sequencing could, in theory, inform disease diagnosis, but this is ...

BCR-ABL forms a dimer and/or tetramer through ... antibody (Calbiochem, San Diego, CA, USA). Cell line dependence on IL-3 and sensitivity to imatinib were tested independently in MTS-based ...

BCR-ABL1 forms when two of your chromosomes accidentally swap DNA during cell division. When this occurs, the ABL1 gene on chromosome 9 fuses with the BCR gene on chromosome 22, creating a new ...

In the study, "Disease diagnostics using machine learning of B cell and T cell receptor sequences," published in Science, researchers analyzed BCR heavy chain and TCR beta chain sequences from 593 ...

achieving up to 1.0 AUROC on independent BCR cohorts and 0.99 AUROC on TCR cohorts after threshold adjustments. Results showed that combined B and T cell analyses outperformed single-locus approaches.

Parse Biosciences, the leader in scalable and accessible single cell sequencing, is pleased to welcome the South Australian Genomics Centre (SAGC) as the newest member of its Certified Service ...

single cell TCR and BCR sequencing and identifying proteins expressed on these cells. The team then verified their findings ...

Empowering researchers to perform single cell sequencing with unprecedented ... Evercode TCR, Evercode BCR, CRISPR Detect, Gene Select, and an interactive data analysis solution, Trailmaker.