We propose that memory B-cell IL-10 production evolved primarily to downregulate vigorous adaptive pathogen-specific immune responses (involving combined TLR, BCR and CD40 signalling) and would ...

In contrast, after adding 20 mg/kg of monoclonal antibody against CD40 ligand to the regimen on days 0 and 2, we observed four thromboembolic complications in nine recipients. These included two ...