A rare autoimmune condition with a tongue-twister of a name may impact people of Puerto Rican heritage through a newly ...

APS 1 is caused by mutations of the autoimmune regulator (AIRE) gene, which encodes an activator of transcription, Aire, that induces the expression of autoantigens in thymic medullary epithelial ...

Notably, the authors’ previous work had shown that vitamin D can enhance the expression of the autoimmune regulator (Aire) gene, and is thus critical for the development of T-cell tolerance and ...

Is it the authors' opinion that we largely rely on infectious agents to generate the regulatory B cells that contribute not only to recovery from exacerbation of autoimmune disease, but also to ...