基因组结构 根据LncRNAs在基因组上相对于蛋白编码基因的位置关系,可以系统的将其分为 (1) Intergenic (LincRNA),(2) Intronic,(3) Bidirectional,(4) Sense-overlapping,(5) Antisense ,(6) Pseudogene这6种类型 (图 1),这种位置关系对于推测lncRNA的功能具有很 ...
Using its expertise in antisense oligonucleotide therapies, it takes only 18–24 months—compared to 4 or 5 years for a small molecule—for HAYA to design cell state-reprogramming, lncRNA ...
为解决肝癌治疗难题,复旦大学附属肿瘤医院的研究人员开展 FAM99B 相关研究。发现 FAM99B 可抑制核糖体生成和肝癌进展,GalNAc - FAM99B65 - 146 有治疗潜力。该研究为肝癌治疗提供新思路,值得科研人员阅读。
Exiqon LNA™ GapmeRs are powerful tools for loss of function studies of proteins, mRNA and lncRNAs. These single strand antisense oligonucleotides catalyze RNase H-dependent degradation of ...