Background: Autoantibodies that produce the homogenous pattern on anti-nuclear antibody-indirect immunofluorescence (ANA-IIF) assay using human epithelial cell (HEp-2) substrate are histones, dsDNA ...
The classic Farr immunoassay for anti-dsDNA employs high concentrations of ammonium sulfate, detecting only high-avidity antibodies, binding in high ionic strength. The salt-resistant anti-dsDNA assay ...