After an accident in a waterfall, the survivors realize that a pack of anacondas have gathered for mating and their nest is nearby the plantation of Blood Orchid, which made them bigger and bigger.

This was followed by one theatrical stand-alone sequel, Anacondas: The Hunt for the Blood Orchid (2004) directed by Dwight H. Little, and three television sequels, Anaconda 3: Offspring (2008 ...