Amplification of the silencing signal in plants may be accomplished by siRNAs priming RNA-directed RNA polymerase (RdRP)-dependent synthesis of new dsRNA. This could be accomplished by RISC ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts ... potentially silencing ...

With recent technological advances, the molecular mechanisms of these RNA silencing pathways are becoming clearly defined, and their components are now being tested in clinical trials.

Newly synthesized vRNAs released from the replication complexes fight against the host’s defense pathways. Therefore, for a robust and productive infection, the viral RNA molecules need to be able to ...