With recent technological advances, the molecular mechanisms of these RNA silencing pathways are becoming clearly defined, and their components are now being tested in clinical trials.

Efficient RNA interference ... exogenous RNAi-induced silencing and their roles in endogenous gene regulation. Although it is too early to assess whether secondary RNAi pathways could be exploited ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi ...

Newly synthesized vRNAs released from the replication complexes fight against the host’s defense pathways. Therefore, for a robust and productive infection, the viral RNA molecules need to be able to ...