研究人员分析 AMPK 复合物磷酸化位点，发现多个 mTORC1 调控底物，为癌症研究提供新思路。 在细胞的微观世界里，代谢调控如同精密的时钟，精准地控制着细胞的生长、增殖和能量平衡。其中，AMP 激活的蛋白激酶（AMPK）和雷帕霉素靶蛋白复合物 1（mTORC1 ...

Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

此外，研究团队还发现，哺乳动物在热量限制期间会积累LCA，并激活一种关键代谢分子——AMPK(AMP激活蛋白激酶)。 AMPK是一种能量感应酶，通常在 ...

Boston, USA-based biotech Nimbus Therapeutics today revealed that, along with partner Eli Lilly, it has achieved a significant pre-clinical milestone in their research collaboration targeting ...

Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK. AMPK ...