The alteplase solution did not clear the occlusion in 2 catheters (3.4%): 1 had a mechanical obstruction and 1 cleared two hours after the 1-mg dose was deemed a failure. None of the six catheter ...

These can sometimes be resolved with an infusion of low-dose alteplase over ... seldom occurs with solutions infused via a PICC, as the infusate exits the catheter at a point with adequate ...