9 In addition, stimulation with adiponectin induces receptor activator of NFκB ligand (RANKL) and downregulates osteoprotegerin synthesis in cultured human osteoblasts, shifting the balance to ...

Adiponectin exerts these effects by binding to two receptors known as PAQR1 and PAQR2 present on the surface of fat cells. PAQR4, a receptor in the same protein family, has an extremely similar ...

accompanied by a significant increase in serum adiponectin levels. The drug's selectivity to the A3 adenosine receptor, which is highly expressed in diseased cells, contributes to its safety profile.