MSS Adenoma-carcinoma sequence 5 (Lynch syndrome) CIMP negative, MSI-H Adenoma-carcinoma sequence CIMP = CpG island methylator phenotype; MSI-H = High-frequency microsatellite instability ...

Figure 2: Contrasting effects of telomere shortening on tumor formation in Apc Min mice. Figure 5: Telomere dysfunction peaks at the adenoma-carcinoma transition in human colorectal carcinogenesis.