Both migration and phagocytosis require actin polymerization, and unsurprisingly, HEM1-deficient neutrophils showed decreased actin polymerization and a diffuse distribution of F-actin.

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

The actin cytoskeleton provides force for dynamic cellular processes, such as motility, morphogenesis, cell division, endocytosis, and phagocytosis. The organization and dynamics of actin filaments ...