Fifteen children with achondroplasia ... and 24 months following initiation of growth hormone (GH) therapy. Before initiating GH therapy, hypothalamic-pituitary and thyroid functions were evaluated.

In the present study, 70 of 75 Japanese patients with achondroplasia were found to have a G1138A mutation in FGFR3, and two patients had a G1138C mutation. Growth hormone therapy was given to 145 ...

Obstructive sleep apnea (OSA) may occur in patients with achondroplasia. Since the bulk of growth hormone (GH) is secreted in relation to slow wave sleep (SWS), disordered sleep may hinder GH ...